Table 1.
Summary of primary subcellular localizations of ZIKV proteins
| ZIKV proteins | cDNA, bp | No. amino acids | Predicted intracellular membrane association* | Intracellular membrane association | Predominant subcellular location | Additional protein features* |
| Structural proteins | ||||||
| anaC | 366 | 122 | Yes | Yes | Nuclear membrane | Nuclear localization signals |
| C | 312 | 104 | Yes | Yes | Nuclear membrane | Nuclear localization signals |
| prM | 504 | 168 | Yes | Yes | ER with speck appearance on cytoplasmic membrane | N-glycosylation |
| M | 225 | 75 | Yes | Yes | ER | |
| Pr | 279 | 93 | No | No | Uniformly distributed with stronger nuclear presentation | |
| E | 1,512 | 504 | Yes | Yes | ER with cytoplasmic specks | Transmembrane helix |
| Nonstructural proteins | ||||||
| NS1 | 1,056 | 352 | No | No | Cytoplasmic puncta | |
| NS2A | 678 | 226 | Yes | Yes | Golgi and low in ER | |
| NS2B | 390 | 130 | Yes | Yes | ER | Cofactor of protease |
| NS3 | 1,851 | 617 | No | No | Uniformly distributed | Protease |
| NS4A | 381 | 127 | Yes | Yes | ER | |
| 2K | 69 | 23 | No | No | Uniformly distributed | |
| NS4B | 753 | 251 | Yes | Yes | ER | |
| NS5 | 2,709 | 903 | No | No | Uniformly distributed | Methyl transferase; RNA-directed RNA polymerase |