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. 2017 Jan 3;114(3):E270–E279. doi: 10.1073/pnas.1614051114

Fig. 3.

Fig. 3.

Distributions of spontaneous Ca2+ release (SCR) amplitude. (A) SCR amplitude (peak [Ca]i) distribution for PCL = 1 s and α = 2.5 (corresponding to Fig. 1B). (B) SCR amplitude distribution for PCL = 1 s and α = 3.3 (corresponding to Fig. 1C). (C) SCR amplitude distribution for four α values (corresponding to Fig. 2B; PCL = 1 s) under the condition in which INa and ICa,L are blocked during diastolic intervals. Block prevents TA initiation and allows us to characterize the distributions over the entire range of SCR amplitude. (D) SCR amplitude distribution for three PCLs (corresponding to Fig. 2C) in which INa and ICa,L are blocked during diastolic intervals. (E) SCR amplitude distribution for the subthreshold DAD at termination of TA (α = 3.1 and PCL = 0.3 s). (F) SCR amplitude distribution obtained using the 11th SCR during which INa and ICa,L are blocked for three different α values (PCL = 0.3 s). The dashed vertical lines denote the [Ca]i thresholds (Cath in Eqs. 2 and 4) for TA initiation in A–D and TA termination in E and F.