Skip to main content
. 2017 Jan 23;7:40764. doi: 10.1038/srep40764

Figure 3. 4R-Tau expression is required during development to impact adult lifespan.

Figure 3

(A) Life span experiment (n = 300 adult females, mean ± SD) showing that 4R-Tau expression throughout development and adulthood (29 °C-29 °C) induced a reduction in the mean life span while adult-onset expression of 4R-Tau (18 °C–29 °C) does not affect the mean life span when compared to control flies. (B) Western blot from adult fly heads showing 4R-Tau adult expression upon temperature switch. The corresponding full-length western blot is presented in Sup Fig. 5B. (C) Life span experiment (n = 200 adult females, mean ± SD) showing that developmental 4R-Tau expression (29 °C–18 °C) is sufficient to induce a reduction in the mean life span. (C) Western blot from adult fly heads showing the persistence of 4R-Tau proteins in adult head despite inhibition of expression upon temperature switch. The corresponding full-length western blot is presented in Sup Fig. 5B.