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. 2017 Jan 23;7:40764. doi: 10.1038/srep40764

Figure 5. 4R-Tau expression delayed mitosis and centrosome dynamics.

Figure 5

(A) Cumulative mitotic timing was calculated in real time using a Jupiter:GFP and Histone:RFP transgene. The mitotic timing started when two Jupiter:GFP foci were on each side of the DNA and ended at telophase. (B) Centrosome movement during mitosis in control cells showing centrosome separation to opposite poles. Each centrosome remains at its pole following nuclear envelop breakdown. (C) Centrosome movement during mitosis in 4R-Tau expressing cells showing that centrosomes are going through several cycles of collapse and separation prior to anaphase onset.