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. 2017 Jan 23;7:40764. doi: 10.1038/srep40764

Figure 7. Monopolar spindle phenotype in human SH-SY5Y neuroblastoma cell line model following expression of wild-type and mutant 4R-Tau isoforms.

Figure 7

(A) Western blot in mock and Tau cell lines showing the increase in Tau protein levels upon tetracycline induction. (B) Quantification of Tau protein level upon tetracycline induction. The corresponding full-length western blot is presented in Sup Fig. 5C. (C) Representative image of a monopolar spindle (arrowhead) close to a normal bipolar spindle (arrow) in Tau-expressing cells (scale bar = 10 μm). (D) Quantification of the percentage of monopolar spindle in the Tau-expressing cells (mean ± SD, the number of monopolar spindles out of the total number of mitotic cells after nuclear envelop breakdown over 3 independent experiments is indicated in the legend of the x-axis).