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. 2017 Jan 23;7:40940. doi: 10.1038/srep40940

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Copyright © 2017, The Author(s)

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The spectrin tetramer is connected with each other and forms a network through the osteocyte. The spectrin network is cross-linked with the F-actin under the plasma membrane. The membrane-associated Ca²⁺ channel, eNOS and connexins were anchored by the spectrin network in the microdomain on the membrane. When disrupted, the anchoring effect of spectrin to Ca²⁺ channel, eNOS and connexins was broken, and caused the influx of Ca²⁺, the translocation of eNOS and the increase of cell-cell connections.