Table 4.

mRNA fold changes in mitochondrial dynamics, mitochondrial biogenesis and synaptic genes in SHSY5Y cells treated with Aβ, curcumin, Aβ+curcumin and curcumin+Aβ relative to untreated SHSY5Y cells

	mRNA fold changes compared with untreated cells				mRNA fold changes compared with Aβ treated cells
Genes	Aβ	Cur	Aβ+Cur	Cur+Aβ	Aβ+Cur	Cur+Aβ
Mitochondrial dynamics genes
Drp1	2.0*	−1.5†	−1.1	1.4	−1.7†	−1.6†
Fis1	2.1*	−1.4†	1.1	1.1	−1.8*	−2.2†
Mfn1	3.0*	1.5†	1.1	1.2	2.8*	3.8*
Mfn2	−1.8*	1.4†	1.1	1.2	1.6†	1.9†
OPA1	−1.6†	1.4†	−1.2	1.0	1.6†	2.2*
Cyclophilin D	2.7*	−1.6†	1.4	1.2	−2.0*	−2.2*
Mitochondrial biogenesis genes
PGC1α	−1.5†	−2.1†	1.0	1.2	1.5†	1.8†
Nrf1	−1.9†	−2.1†	−1.2	1.1	1.6†	2.2*
Nrf2	−2.6*	−1.4†	−1.4	1.1	1.9†	2.3*
TFAM	−1.7*	−1.8*	1.0	1.2	1.8†	1.8†
Synaptic genes
Synaptophysin	−2.3*	−1.6*	1.4	1.2	3.2*	2.6*
PSD-95	−1.6†	−1.2	1.0	1.0	1.6†	1.9†

*p≤0.005.

†p≤0.05.

Aβ, amyloid β; Cur, curcumin.