Figure 1.

Experimental design. All mice were infected with 1 × 10⁵ colony‐forming units (CFUs) of Streptococcus pneumoniae by intranasal route. Selected groups of mice were administered PBS (placebo), antalarmin (1 mg/kg), CRH (1 mg/kg), or dexamethasone (1 mg/kg) by intranasal route at designated time points 9 h (A), 18 h (B), and 30 h (C). Selected groups of mice were sacrificed 6 h after administration of drug for analysis. Additional groups of mice were monitored for survival.