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. 2017 Jan 13;5(1):e13100. doi: 10.14814/phy2.13100

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© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Changes in core temperature do not affect the proportionality of the lipopolysaccharide (LPS)‐induced changes in respiratory exchange ratio and pH. This analysis was made for the responses to LPS O55:B5 at the shock‐inducing dose of 0.5 mg/kg. Two groups of rats with opposite core temperature responses were compared: hypothermia at an ambient temperature of 22°C versus fever at an ambient temperature of 29°C. Means ± standard errors are shown for the data obtained at 60 min before LPS and 60 min after LPS.