Table 6. Factors associated with incidence rate of effectiveness rate: univariate analysis.

Variable	Improvement	No improvement	p-value
History of exacerbation
Yes	182 (91.00)	18 (9.00)	0.004
No	562 (96.23)	22 (3.77)
Smoking history
Ex-smoker	444 (95.69)	20 (4.31)	0.048
Smoker	140 (90.91)	14 (9.09)
Non-smoker	149 (96.13)	6 (3.87)
Average daily dose, µg
150	679 (95.77)	30 (4.23)	0.003*
≥150 and <300†	11 (100)	0 (
300	54 (84.38)	10 (15.63)

Values are presented as number (%).

p-value by chi-square test.

^*By Fisher's exact test. ^†Total daily dose was divided by treatment days (dose change during treatment period).