Skip to main content
. 2016 Jul 13;66(1):59–69. doi: 10.1136/gutjnl-2015-310874

Figure 2.

Figure 2

Administration of a clinically relevant low dose of thioguanine (TG) improved spontaneous Winnie colitis. (A–C): Winnie mice were daily gavaged with either TG 0, 0.5 or mercaptopurine (MP) 2.5 mg/kg/day for 28 days. (A) Peripheral white blood cell (WBC) count; (B) combined diarrhoea score one-way ANOVA p<0.05 at 28 days and (C) histological colitis scores for proximal colon (PC) and distal colon (DC) in Winnie. (D and E) Acute administration of TG in Winnie and RaW (Rag−/−×Winnie) mice daily gavaged TG 0 or 2.5 mg/kg/day for up to 14 days; (D) histological colitis scores for PC and DC in Winnie (light grey symbols) and RaW (dark symbols); (E) representative H&E/Alcian blue staining for DC of Winnie and RaW mice treated with daily TG 0 or 2.5 mg/kg for 12 days. Statistical analysis: Mann-Whitney non-parametric test. Symbols:*versus Winnie TG 0 mg/kg; #versus RaW TG 0 mg/kg.