Table III.
Relevant Plasma Compartmental Pharmacokinetic Parameters of S-AR-42 in Rats (n = 6) Following I.V. and P.O. Administration
| PK parameters | Average | SD | CV (%) |
|---|---|---|---|
| I.V. administration (20 mg/kg) | |||
| C 0 (μM) | 35.6 | 24.9 | 70.0 |
| α (h−1) | 7.6 | 4.7 | 62.2 |
| T 1/2 α (h) | 0.12 | 0.07 | 57.1 |
| β (h−1) | 0.22 | 0.09 | 40.5 |
| T 1/2 β (h) | 5.1 | 2.6 | 51.0 |
| MRT (h) | 6.5 | 3.7 | 56.7 |
| Cl (l/h/kg) | 1.8 | 0.6 | 33.0 |
| Vss (l/kg) | 11.0 | 5.5 | 49.5 |
| AUC0-∞ (μM×h) | 39.8 | 14.4 | 36.1 |
| P.O. administration (50 mg/kg) | |||
| C max (μM) | 7.1 | 1.6 | 23.2 |
| T max (h) | 3.3 | 4.5 | 137 |
| λz (h−1) | 0.09 | 0.04 | 37.4 |
| HL-λz (h) | 9.3 | 6.4 | 68.5 |
| Vz/F (L/kg) | 13.7 | 12.1 | 88.2 |
| AUMC (μM×h2) | 3242 | 704 | 21.7 |
| MRT (h) | 19.5 | 5.6 | 28.7 |
| Cl/F (l/h/kg) | 1.0 | 0.2 | 17.7 |
| AUC0-∞ (μM×h) | 171 | 30.9 | 18.1 |
SD standard deviation determined from n = 6 estimates; CV (%) coefficient of variation determined by SD/average*100%