Table III.

Pediatric and adult biopharmaceutical classification system of the 38 oral drugs used in the study

	Biopharmaceutical classification system
	Newborn (neonate)	Age (years)																		Adult
		0.5	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17
Albendazole	Not given to this subpopulation			II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Amitriptyline	Not given to this subpopulation			II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Amoxicillin	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	III	III	III	III	III	III	III
Azithromycin	Not given to this subpopulation	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Carbamazepine	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Cefalexin	IV	IV	IV	IV	IV	IV	III	IV	IV	IV	IV	IV	IV	III	III	III	III	III	III	III
Chloramphenicol	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	III	III	III	III	III	III	III	III	III	III
Ciprofloxacin	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III
Clindamycin	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV
Cloxacillin	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Cyclizine	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I
Dexamethasone	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I
Diazepam	II	II	II	II	I	I	II	II	II	II	I	I	I	II	II	II	I	I	I	I
Diethylcarbamazine	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III
Doxycycline	Not given to this subpopulation													IV	IV	IV	IV	IV	IV	III
Erythromycin	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	I
Ethosuximide	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III
Fluoxetine HCl	Not given to this subpopulation										I	I	I	I	I	I	I	I	I	I
Ibuprofen	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Ivermectin	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Levamisole HCl	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I	I
Loratadine	Not given to this subpopulation			II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Mebendazole	Not given to this subpopulation	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Metronidazole	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III
Midazolam	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Morphine	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III
Niclosamide	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Nitrofurantoin	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV
Oxamniquine	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV
Paracetamol	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III
Phenobarbital	IV	IV	IV	IV	IV	IV	IV	IV	IV	III	III	III	III	III	III	III	III	III	III	III
Phenoxy-methylpenicillin	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III	III
Phenytoin	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Praziquantel	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II
Prednisolone	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	III	III	III	III	III	III	III	III	III
Sulfamethoxazole	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV
Trimethoprim	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	IV	III	III	III	IV
Valproic acid	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II	II

Italicized drugs are the drugs that did not change their solubility class; drugs in bold are the drugs that change their solubility class