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Geometric mean PK profiles from clinical single ascending dose studies with AZD1283. The open circles, squares, diamonds and triangles represent geometric mean plasma concentrations of AZD1283 determined in cohorts (n = 2 to 6 male healthy volunteers) receiving 50, 250, 750 or 2000 mg. The dotted line is the estimated biological effective target concentration derived from the quantitative PK/PD efficacy relationship in the anaesthetized dog anti-thrombotic model
