Fig. 1.

Re-analysis of the effects of interleukin (IL)-6 on modulation of CYP1A2 and CYP3A4. The inhibitory effect of IL-6 on CYP3A4 activity was presented with 6β-hydroxytestosterone formation from testosterone (a). The bell-shaped effect of IL-6 on CYP1A2 activity over the wide concentration range (1–50,000 pg/mL) (b) and the inductive effect of IL-6 on CYP1A2 activity at the lower concentration range (1–100 pg/mL) (c) were presented with acetaminophen formation from phenacetin. Symbols represent individual observed data digitized from literature (5). Data were fit to a variable slope dose–response model, and lines represent model estimation results