. 2016 Mar 9;18(3):767–776. doi: 10.1208/s12248-016-9890-5

Table I.

CYP Enzyme Regulation Parameters by IL-6 for PBPK Model Input

Parameters (unit)	Values
E _{max_CYP1A2} ^a	1.34
EC_{50_CYP1A2} ^a (pg/mL)	8.0
E _{min_CYP2C9} ^b	0.053
EC_{50_CYP2C9} ^b (pg/mL)	121.0
E _{min_CYP2C19} ^b	0.214
EC_{50_CYP2C19} ^b (pg/mL)	71.3
E _{min_CYP3A4} ^c	0.25
EC_{50_CYP3A4} ^c (pg/mL)	75.2
E _{min_CYP3A5} ^b	0.034
EC_{50_CYP3A5} ^b (pg/mL)	51.0

CYP cytochrome P450, PBPK physiologically based pharmacokinetic model

^aValues were obtained by simultaneous fitting of effect of IL-6 on CYP1A2 activity data from literature (5) with the log (agonist) versus response model. The E _{max_CYP1A2} value used as PBPK model input was derived by normalizing model fitted value of E _max to that of baseline activity value (E _min), which was 107.5 and 80.33%, respectively

^bValues were obtained by directly applying effect of interleukin-6 (IL-6) on CYP enzyme messenger RNA expression values reported in literature (5)

^cValues were obtained by simultaneous fitting of effect of IL-6 on CYP3A4 activity data from literature (5) with the log (inhibitor) versus response model