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Net Internalization Rates (k e) and Half-Lives (t 1/2) for Tras-647 and TM-ADC-647
| Tras-647 | TM-ADC-647 | Significantly different? p value | |||
|---|---|---|---|---|---|
| Cell line | k e(h− 1) | t 1/2(h) | k e(h− 1) | t 1/2(h) | |
| BT-474 | 0.054 ± 0.007 | 12.8 | 0.11 ± 0.02 | 6.3 | <0.0001 |
| NCI-N87 | 0.035 ± 0.008 | 19.8 | 0.051 ± 0.006 | 13.6 | <0.01 |
| SK-BR-3 | 0.043 ± 0.005 | 16.1 | 0.09 ± 0.01 | 7.7 | <0.000001 |
