Table II.

Best Fitted, Minimal, and Maximal Values of Parameters in the Human PBPK Model for Rosuvastatin and Resulting Kp _uu Values

Parameter	Best fitted value	Minimum	Maximum
CL act (L/h)	2266	137	3260000
CL pass (L/h)	6.63	0.0552	6420
CL bile (L/h)	2.51	0.518	46.3
F a	0.380	0.0989	0.835
k a,1 (h−1)	0.0147	0.00147	0.143
k a,2 (h−1)	0.509	0.0510	4.53
F abosprition,1	0.382	0.0671	0.969
Kp uu	454	4.36	2662