Table I.
Tissue Distribution and Recovery
| Sample/organ | Relative amount of radioactivity [μCi/g tissue] | Total amount of radioactivity [μCi] | % of radioactivity recovered |
|---|---|---|---|
| Administration | |||
| Total amount administered | 1432 (3.44) | ||
| Recovery | |||
| Blooda | 0.240 (12.2) | 3.47 | 0.242 (26.8) |
| Liver | 1.19 (13.7) | 11.4 | 0.796 (5.99) |
| Kidney | 7.92 (8.98) | 16.4 | 1.15 (10.9) |
| Lung | 0.635 (9.35) | 0.805 | 0.056 (12.1) |
| Spleen | 0.688 (11.5) | 0.658 | 0.046 (13.8) |
| Heart | 0.224 (9.32) | 0.219 | 0.015 (24.9) |
| Brain | 0.104 (18.1) | 0.160 | 0.011 (39.6) |
| Muscle | 0.228 (21.8) | 24.7 | 1.72 (34.9) |
| Urinea | 17.9 (21.2) | 1003 | 70.0 (2.99) |
| Fecesb | 5.91 (39.6) | 181 | 12.6 (29.8) |
| Total amount recovered | 1242 | 86.6 (5.09) | |
Recovery of radioactivity following IV administration of 3H-1329 (0.9 mg/kg, BID for 4.5 days) in rats. All values are expressed as mean (%CV)
aIn μCi/mL
bIn μCi/g feces