Table 4. Univariate and multivariate logistic regression analyses predicting factors for creatinine elevation of ≥ 0.5 mg/dL.

Characteristics	Univariate analysis			Multivariate analysis
	HR	95% CI	P-value	HR	95% CI	P-value
Age, years	1.076	1.001–1.156	0.046
Sex, male	0.295	0.064–1.359	0.117
Cirrhosis	13.238	1.561–112.272	0.018	34.365	1.259–938.149	0.036
TDF monotherapy vs. TDF combination therapy	0.806	0.152–4.263	0.800
DM	6.787	1.417–32.513	0.017	48.425	1.928–1216.556	0.018
HTN	14.828	2.746–80.066	0.002
CKD	115.200	12.632–1050.548	< 0.001
NA-naïve vs. NA-experienced	1.478	0.322–6.792	0.001
ADV experienced vs. non-experienced	0.368	0.043–3.119	0.359
BMI	0.847	0.652–1.099	0.211
Initial eGFR	0.935	0.905–0.967	< 0.001	0.901	0.844–0.961	0.002

HR, hazard ratio; CI, confidence interval; TDF, tenofovir disoproxil fumarate; DM, diabetes mellitus; HTN, hypertension; CKD, chronic kidney disease; NA, nucleos(t)ide analogue; ADV, adefovir; BMI, body mass index; eGFR, estimated glomerular filtration rate.