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. 2017 Jan 23;12(1):e0170232. doi: 10.1371/journal.pone.0170232

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© 2017 Maharana et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 7 — (A) First type-III interface interaction mode, where type-IIIa interface of NOD1^CARD is found interacting with type-IIIb patch of RIP2^CARD; (B) Second type-III mode of interaction (type-IIIa patch of RIP2^CARD interacts with type-IIIb patch of NOD1^CARD). Left panel of both the figures shows the conserved interactions (taken from S7C and S8C Figs), which are mediated by type-III interfaces of NOD1 and RIP2 CARDs; middle panel displays respective inter-residual/interatomic distance graphs. The detailed type-III modes of interactions (along with inter-interface contacts) were depicted in the right panel. The critical residues involved in intermolecular interactions were portrayed in ball and stick model, and were coloured based on physicochemical parameters. NOD1 and RIP2 CARDs models were visualized in white and orange cartoon for better understanding. The black dotted lines represent the inter/intra-molecular polar contacts. The residues labelled in different colour fonts symbolizes the interface types (blue: type-IIa; orange: type-IIb; green: type-IIIa; magenta: type-IIIb).