TABLE 8.
Upstream regulatory molecules in AR, APN culture-positive, APN culture-negative, native pyelonephritis using Ingenuity pathway analysis, showing z-scores. © 2000–2015 QIAGEN. All rights reserved
| Upstream regulators |
AR | APN culture positive |
APN culture negative |
NP |
|---|---|---|---|---|
| IL-27 | 4.658 | 3.8935 | 4.3333 | 3.503 |
| EBI3 | 3.8312 | 3.4218 | 3.6996 | 2.7894 |
| IFNG | 3.2101 | 2.6045 | 2.9437 | 0.9913 |
| MAPK1 | −3.3264 | −2.3757 | −2.8673 | −0.9045 |
| IRF4 | −3.05796 | −2.7196 | −3.3023 | 0.2182 |
| Interferon- alpha |
3.08814 | 1.6787 | 2.9861 | 0.3428 |
| IL-12 (complex) | 2.9496 | 1.708 | 2.7634 | 1.6843 |
| IFNL1 | 2.7997 | 2.1783 | 2.6186 | 0.2773 |
| ERK1/2 | −1.0566 | 0.6602 | 0.4849 | 2.9153 |
| IL-18 | 2.4275 | 1.8676 | 2.6921 | 1.0687 |
| TNF | 2.4727 | 1.7964 | 2.0825 | 0.5429 |
| STAT1 | 1.66119 | 0.4527 | 1.6666 | 0.239 |
| P38 MAPK | 1.3962 | 1.5366 | 2.1335 | 0.7475 |
| NFkB (complex) | 1.35419 | 0.5369 | 0.5166 | 0.0143 |
| BCR (complex) | 0.63907 | 1.0397 | 1.3655 | 2.1801 |
Orange—predicted activation; blue—predicted inhibition; white—no prediction can be made and darker colors indicate higher z-score.