Fig. 9.

A.  <u² > from neutron scattering of binary trehalose glasses as a function of glycerol mass fraction. Inset shows enzyme deactivation times in trehalose glasses with varying glycerol content. Higher deactivation times are observed at the same glycerol fraction at which  <x² > is smallest at most temperatures, as pointed by the black arrows. Error bars represent ± 1 standard deviation. B. Correlation between  <u² > and aggregation and chemical degradation rates of freeze-dried proteins in sugar glasses is from Ref. [81] . Each label represents a different protein and/or sugar matrix for either aggregation or chemical destabilization.

Source: Figure is adapted from references [81], [115] . Used with permission from Elsevier and the Royal Society of Chemistry.