Table 1.
Demographic, Clinical, and Recanalization Variables of Patients With NI (Patients 1–12) and Without NI (Patients 13–17)
| Patient No./ Sex/Age, y |
NIHSS Scorea | Pre-tPA BP, mm Hg |
24-h Post-tPA BP, mm Hgb |
BP Treatmentc |
Decline in SBP ≥20 mm Hg |
NI + Decline in SBP ≥20 mm Hg |
Recanalization 24-h MRA |
|
|---|---|---|---|---|---|---|---|---|
| Pre-tPA | At 24 h |
|||||||
| 1/F/81 | 1 | 0 | 160/59 | 145/63 | No | No | No | Complete |
| 2/M/65 | 5 | 0 | 126/88 | 122/86 | No | No | No | Complete |
| 3/F/84 | 25 | 17 | 135/82 | 158/89 | No | No | No | None |
| 4/F/63 | 9 | 3 | 127/74 | 125/83 | No | No | No | None |
| 5/M/67 | 11 | 2 | 151/77 | 112/61 | No | Yes | Yes | Partial |
| 6/F/83 | 15 | 10 | 162/84 | 136/65 | Yes | Yes | Yes | Partial |
| 7/F/47 | 6 | 0 | 144/96 | 124/73 | No | Yes | Yes | Partial |
| 8/F/83 | 8 | 0 | 172/78 | 131/60 | No | Yes | Yes | Complete |
| 9/F/83 | 24 | 14 | 144/87 | 108/66 | No | Yes | Yes | Partial |
| 10/F/92 | 23 | 14 | 165/82 | 125/77 | No | Yes | Yes | Complete |
| 11/F/88 | 21 | 10 | 211/147 | 149/92 | Yes | Yes | Yes | Complete |
| 12/F/83 | 27 | 12 | 172/81 | 148/78 | No | Yes | Yes | Complete |
| 13/F/79 | 4 | 7 | 159/93 | 143/78 | No | No | No | Partial |
| 14/M/54 | 17 | 14 | 145/84 | 127/69 | Yes | No | No | Partial |
| 15/M/74 | 13 | 20 | 153/74 | 160/70 | No | No | No | Partial |
| 16/F/94 | 20 | 25 | 173/85 | 147/65 | No | Yes | No | Partial |
| 17/F/74 | 26 | 23 | 150/115 | 119/52 | Yes | Yes | No | None |
Abbreviations: BP, blood pressure; F, female; M, male; MRA, magnetic resonance angiography; NI, neurologic improvement; NIHSS, National Institutes of Health Stroke Scale; SBP, systolic blood pressure; tPA, tissue plasminogen activator.
a
NI defined as improvement in NIHSS score of 4 or more points or NIHSS score of 0 at 24 hours post-tPA treatment.
b
Average of the last 3 hourly readings of BP prior to 24-hour MRA.
c
Treatment with intravenous antihypertensives in the first 24 hours per tPA monitoring protocol.