Task design and behavioral results. (A) Schematic of the working memory updating task. The three task conditions (Remember Face, Remember Scene, and Remember Both) were indicated by the cue word displayed after the presentation of the two picture stimuli, instructing the participants to remember only the face, scene, or both pictures, respectively. For simplicity, the visual mask and ITI (8–12 s) were not shown in the figure. (B) Mean accuracy (± standard error of the mean [SEM]) for each group by cue type. The MDD participants performed significantly worse on the Remember Scene condition compared to healthy controls (corrected for multiple comparisons). (C) Mean response time (± SEM) for each group by cue type. ** p ≤ 0.03.