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. Author manuscript; available in PMC: 2017 Jan 23.
Published in final edited form as: Oral Oncol. 2016 Aug 21;61:159–165. doi: 10.1016/j.oraloncology.2016.08.003

Figure 1. IFN-I signaling in cancer regulates its immunogenicity.

Figure 1

“Hot” immunogenic tumors could be better recognized by the immune system than “cold” tumors. IFN-I-derived from cancer cells could launch a large interferon-stimulated genes (ISG) transcriptional program and promote effector immune cell trafficking to the tumor bed. In addition, IFN-I could also promote APC cross-priming of T-cells.