Table 2.
Multivariate Model for Association of UCLA Loneliness Scale With Amyloid Burdena
| Predictor | β Estimate (95% CI) | Standardized β (SE) | P Value |
|---|---|---|---|
| Amyloid burden in PiB DVR (unit = 1) | 3.3 (1.2 to 5.3) | 0.38 (1.03) | .002 |
| Age | −0.10 (−1.50 to −0.04) | −0.34 (0.03) | .002 |
| Male sex | 0.009 (−0.787 to 0.804) | 0.002 (0.400) | >.99 |
| Hollingshead | −0.002 (−0.027 to 0.024) | −0.12 (0.01) | .90 |
| GDS | 0.17 (0.05 to 0.28) | 0.32 (0.06) | .005 |
| HADS-anxiety | 0.06 (−0.09 to 0.21) | 0.09 (0.08) | .43 |
| Social network | −0.05 (−0.44 to 0.34) | −0.03 (0.20) | .81 |
| Positive APOEε4 carrier status | −0.90 (−1.87 to 0.02) | −0.23 (0.47) | .06 |
Abbreviations: APOEε4, apolipoprotein E ε4; DVR, distribution volume ratio; GDS, Geriatric Depression Scale–30 item; HADS, Hospital Anxiety and Depression Scale; PiB, Pittsburgh Compound B.
a
F64 = 3.8, P = .001, and adjusted R2 = 0.23.