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Anti-Dsg IgG autoantibodies in pemphigus. Two kinds of IgG autoantibodies have been characterized in pemphigus, anti-Dsg1 and anti-Dsg3 IgG. Cross-reactivity between Dsg1 and Dsg3 is only occasionally found in pemphigus sera. The identification of the Dsg4 isoform and the characterization of its involvement in pemphigus have revealed that anti-Dsg4 IgG is a cross-reacting subset of anti-Dsg1 IgG.
