. 2016 Apr 6;89(1062):20150930. doi: 10.1259/bjr.20150930

Table 4.

Summary of reports on acute toxicities in whole-pelvic radiotherapy (WPRT) vs prostate-only radiotherapy (PORT) with dose escalation to the prostate

Study	Technique	Treatment site	Patients (n)	Total dose (Gy)/number of fractions		Acute GI toxicity (%)			Acute GU toxicity (%)
Study	Technique	Treatment site	Patients (n)	Prostate	Whole pelvis	Grade 3	Grade 2	p-value	Grade 3	Grade 2	p-value
Aizer et al³¹	3D-CRT, IMRT	WPRT	68	75.6/42	45/25	10	34	0.048	2	18	0.090
Aizer et al³¹	3D-CRT, IMRT	PORT	209	75.6/42	–	6	25	0.048	3	7	0.090
Guckenberger et al²⁸	IMRT	WPRT	25	73.91–76.23/32–33	46/25	0	12	1.00	0	44	0.81
Guckenberger et al²⁸	IMRT	PORT	75	73.91–76.23/32–33	–	0	12	1.00	5	36	0.81
Deville et al¹⁰	IMRT	WPRT	30	79.2/44	45/25	0	50	0.006	3	50	0.587
Deville et al¹⁰	IMRT	PORT	30	79.2/44	–	0	13	0.006	0	50	0.587
Current study	VMAT	WPRT	119	78/39	46.8/26	0	14	0.066	0	13	0.620
Current study	VMAT	PORT	105	78/39	–	0	7	0.066	0	11	0.620

3D-CRT, three-dimensional conformal radiotherapy; GI, gastrointestinal; GU, genitourinary; IMRT, intensity-modulated radiotherapy; VMAT, volumetric-modulated arc therapy.