Expansion and productive HIV-1 infection of Foxp3 positive CD4 T cells at pleural sites of HIV/TB co-infection

. Author manuscript; available in PMC: 2017 Jan 23.

Published in final edited form as: J Clin Exp Immunol. 2016 Oct 31;1(1):http://www.opastonline.com/wp-content/uploads/2016/11/expansion-and-productive-hiv-1-infection-of-foxp3-positive-cd4-t-cells-at-pleural-sites-of-hivtb-co-infection-jcei-16-007.pdf.

CD4⁺Foxp3⁺ CD127⁻ and CD4⁺Foxp3⁻CD127⁺ in PFMC from HIV/TB patients (n=6) were characterized for their expression of HIV-1 p24 and IFN-γ. A. Algorithm for assessment of frequencies of CD4⁺Foxp3⁺ CD127⁻ and CD4⁺Foxp3⁻CD127⁺ PFMC co-expressing HIV p24 and IFN-γ alone or in combination. B. Among CD4⁺Foxp3⁺ CD127⁻ T cells, higher frequencies of HIV-1 p24⁺ (p<0.01), IFN-γ⁺ (p<0.01) and dual HIVp24⁺IFNγ⁺ (P<0.05) as compared to CD4⁺Foxp3⁻CD127⁺ T cells were found.

Figure 2. Frequencies of CD4+Foxp3+ CD127− and CD4+Foxp3−CD127+ PFMC co-expressing HIV-1 p24 alone or in combination with IFN-γ.

Figure 2. Frequencies of CD4⁺Foxp3⁺ CD127⁻ and CD4⁺Foxp3⁻CD127⁺ PFMC co-expressing HIV-1 p24 alone or in combination with IFN-γ.