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. Author manuscript; available in PMC: 2017 Jan 23.
Published in final edited form as: J Clin Exp Immunol. 2016 Oct 31;1(1):http://www.opastonline.com/wp-content/uploads/2016/11/expansion-and-productive-hiv-1-infection-of-foxp3-positive-cd4-t-cells-at-pleural-sites-of-hivtb-co-infection-jcei-16-007.pdf.

Figure 5. Resistance to apoptosis and differential expression of Bcl2 in PFMC subpopulations in HIV/TB co-infected patients.

Figure 5

In A, apoptosis of CD4+CD25hi+T cells and CD4+CD25lo/− T cells were assessed by TUNEL methodology (n=10). In B and C PFMC from HIV/TB patients were assessed for co-expression of intra-cellular Foxp3, HIV-1 p24 and Bcl-2 (n=16). A. Frequencies of TUNEL positive CD4+CD25lo/− T cells exceeded those of CD4+CD25hi+ T cells by 3.7 fold (P < 0.001). B. Frequencies of HIV-1 p24+Foxp3+ CD4 T cells co-expressing Bcl-2 exceeded HIV-1 p24+Foxp3− T cells by more than 5 fold (p < 0.001). C. Among Foxp3 positive CD4 T cells, intracellular expression of Bcl-2 was enriched among HIV-1 p24+ as compared to HIV-1 p24− CD4 T-cell subsets (p<0.001) (n=16).