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. 2016 Oct 20;35(1):61–73. doi: 10.1002/jor.23452

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© 2016 The Authors. Journal of Orthopaedic Research published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Anabolic and catabolic gene expression in a micropellet configuration: Configuration and co‐culture reduce catabolic upregulation in inflammatory and hypoxic conditions. Aggrecan (A), collagen 2A1 (B), MMP‐1 (C), MMP‐9 (D), MMP‐13 (E), and ADAMTS5 (F) gene expression in MSC‐only, NPC‐only, and co‐culture micropellet groups after 21 days in basal or hypoxic and inflammatory media conditions. Fold changes for each gene were normalized to the co‐culture individual cell basal media group, which is shown in Figure 3. The + symbol indicates a significant difference (p < 0.05) within a cell type group for different media conditions, while the * symbol indicates a significant difference between different cell type groups under the same media conditions. Error bars represent standard deviation.