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. 2016 Oct 20;35(1):61–73. doi: 10.1002/jor.23452

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© 2016 The Authors. Journal of Orthopaedic Research published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society.

This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Co‐culture and micropellet configurations exhibit reduced catabolic induction. Fold induction of catabolic markers MMP‐1 (A), MMP‐9 (B), MMP‐13 (C), and ADAMTS5 (D) represents the fold change between basal and hypoxic/inflammatory media conditions (normalized separately to the basal media condition for each group, which is not shown in the graph). The + and # symbols indicate a significant (p < 0.05) increase and decrease, respectively in expression in degenerative media conditions. Error bars represent standard deviation.