Fig. 2. CXCL9 and CXCL10 are expressed with different kinetics during the progression of vitiligo in mice.
a. Representative flow plots depicting chemokine reporter expression in the epidermis during vitiligo progression. b. Quantification of chemokine reporter expression in the epidermis of vitiligo mice. c. Melanocyte-specific (PMEL) and endogenous T cell infiltration in the epidermis during vitiligo. d. Scores of all animals used for REX3 analysis. e. CXCL9 and f. CXCL10 reporter expression in active and stable mice. g. Receiver operator characteristics (ROC) curves for CXCL9 and CXCL10 as biomarkers of disease activity. h. CXCL9 and i. CXCL10 reporter expression in severe, mild, or naïve mice. j. ROC curves for CXCL9 and CXCL10 as biomarkers of disease severity. (n=19 naïve mice, 5 mice at week 3, 9 at week 5, 12 at week 7, and 9 at week 10 pooled from 2 to 3 separate experiments; mean ± SEM).