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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: J Invest Dermatol. 2016 Sep 26;137(2):350–358. doi: 10.1016/j.jid.2016.09.016

Fig. 5. Keratinocyte responses to IFN-γ are required for vitiligo induction in mice, whereas other epidermal cell types are dispensable.

Fig. 5

a. Mice with keratinocytes unable to respond to IFN-γ (STAT1-flox +/+ K5-cre+) were significantly protected from vitiligo compared to littermate control mice. b. Mice lacking gamma-delta T cells (TCRδ−/−), c. Langerhans cells (hu-Langerin DTA), or d. bystander CD8+ T cells (CD8−/−) did not have significantly different average disease scores as compared to WT controls. e–h. Number of PMEL T cells in the epidermis of STAT1-flox +/+ K5-cre+, TCRδ −/−, hu-Langerin DTA, or CD8−/− mice compared to controls. Each symbol represents data from an individual animal, pooled from 3–4 separate experiments.

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