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. 2017 Jan 24;11:4. doi: 10.3389/fncel.2017.00004

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Copyright © 2017 Xu, Chen, Hu, Huang and Hu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dibutyryl cyclic adenosine monophosphate boosts axon regeneration and promotes mitochondrial motility. (A,B) The axon regeneration in vehicle- and db-cAMP-treated zebrafish at 2 dpa. (C) The kymographs display axonal transport of mitochondria before and after vehicle and db-cAMP treatments. Right kymographs are hand-drawn traces corresponding to the left kymographs (anterograde, blue lines; retrograde, pink lines). (D–F) Mitochondrial motility (D), transport direction (E), and speed (F) before and after vehicle and db-cAMP treatments. Scale bar: (A) 100 μm. ^∗p < 0.05, ^∗∗p < 0.01. Error bars represent SEM.