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. 2017 Jan 24;7:678. doi: 10.3389/fphys.2016.00678

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Copyright © 2017 Glatt, Evans and Tetsworth.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Micro-computed tomography (μCT) and histology images illustrating healing of segmental defects with 11 and 5.5 μg doses of BMP-2, high and low stiffness external fixator groups as well as a Reverse Dynamization group (RD) after 8 weeks of treatment. μCT images of cross-sectional distal part of the defect (top row) and coronal plane of the defect (middle row). Histological sections were stained with safranin orange-fast green (bottom row, Scale bar = 1 mm). Low = low stiffness fixator (114 N/mm); High = high stiffness fixator (254 N/mm); RD = low to high stiffness fixation at 2 weeks (from Glatt et al., 2012b, 2016a).