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. 2017 Jan 24;8:46. doi: 10.3389/fmicb.2017.00046

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Copyright © 2017 Fleming, McCaughan, Lateef, Dunn, Wise, Real and Mercer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Histopathology of ORFV infected skin tissue. H & E stained sections from biopsy tissue at day 4 p.i., dose 10⁷ of p.f.u. virus. (A) mock-infected (PBS) skin (B) CBP_FLAG -revertant showing histological features of infected tissue (C,D) histological features of CBP-knockout virus (E) CBP-revertant virus infected tissue showing parakeratosis and necrotic keratinocytes (F) wt infected tissue showing hyperkeratosis. The images were taken at 40X magnification.