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. 2017 Jan 24;8:18. doi: 10.3389/fphys.2017.00018

Figure 2.

Figure 2

No effect of L-arginine (100 μM) pre-incubation (7 min) (bl.) on the ATP-induced inhibition of NaCl absorption in isolated perfused mouse mTAL. (A) Representative original trace of the basolateral ATP effect in mouse mTAL in the presence or absence of L-arginine. The order of applying ATP with or without L-arginine was alternated. Recording of the electrical parameters Vte (transepithelial voltage) and ΔV0 (voltage deflection) in freshly dissected and perfused mouse mTAL used to quantify transport changes. (B) Summary: calculated ATP-induced changes of the equivalent short-circuit current (I'sc) with pre-incubation of L-arginine (n = 5, *p < 0.05 by student's T-test). (C) Summary: calculated ATP-induced changes of the equivalent short-circuit current (I'sc) without pre-incubation with L-arginine (n = 5, *p < 0.05 by student's T-test). (D) Summary: ATP inhibited I'sc with and without L-arginine.