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. 2017 Jan 24;8:18. doi: 10.3389/fphys.2017.00018

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Copyright © 2017 Svendsen, Isidor, Praetorius and Leipziger.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The nitric oxide donors SNAP and Spermine NONOate have no influence on NaCl absorption in isolated perfused mouse mTAL. (A) Representative original trace of the effect of basolateral SNAP (100 μM given for 10 min) in mouse mTAL. Recording of the electrical parameters V_te (transepithelial voltage) and ΔV₀ (voltage deflection) in freshly dissected and perfused mouse mTAL used to quantify transport changes. After wash-out of SNAP basolateral ATP (100 μM) was given to test the tubule's functional viability. (B) Summary: calculated equivalent short-circuit current (I'_sc) of n = 4 experiments before, during (after 10 min) and after SNAP wash-out (4 min after). (C) Representative original trace of the effect of basolateral Spermine NONOate (10 μM given for 10 min) in mouse mTAL. Recording of the electrical parameters V_te (transepithelial voltage) and ΔV₀ (voltage deflection) in freshly dissected and perfused mouse mTAL used to quantify transport changes. (D) Summary: calculated equivalent short-circuit current (I'_sc) of n = 4 experiments before, during (after 10 min) and after Spermine NONOate wash-out (4 min after).