Skip to main content
. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Hepatology. 2016 Aug 29;65(2):501–514. doi: 10.1002/hep.28735

Figure 4. miR-195-loaded EVs inhibit CCA growth and increase survival in vivo.

Figure 4

A: LX2 EVs were loaded with either (left panels) a non-specific miR mimic NSM (negative control), or (right panels) a miR-195 mimic. Examination of (upper panels) entire liver and (lower panels) excised tumor revealed that tumors were significantly smaller in animals that had been injected with miR-195-loaded EVs. B–D: Tumor weight and volume of cancers from rats treated with miR-195 EVs treated was less vs. EV-NSM treated CCA rats (n=3). Statistical significance was analyzed using two-tailed Student’s t-test: *P<0.05. E: In vivo treatment of CCA with EVs-miR-195 increases the survival by 28.7%. Twenty cancer bearing rats were randomly divided in 2 groups: 11 were treated with EVs-miR-195 and 9 were treated with EVs-NSM (negative control). *P=0.013