Table 2a.
Univariate Cox regression analysis for relapse-free survival.
| Covariate | HR | 95% CI | P value | |
|---|---|---|---|---|
| Age | 1.02 | 0.99 | 1.05 | 0.128 |
| log(WBC) | 0.94 | 0.72 | 1.22 | 0.622 |
| HGB | 1.05 | 0.83 | 1.34 | 0.672 |
| log(PLT) | 0.94 | 0.66 | 1.33 | 0.712 |
| log(Blast) | 0.93 | 0.75 | 1.15 | 0.509 |
| log(mono) | 1.02 | 0.78 | 1.34 | 0.863 |
| log(neutrophils) | 1.15 | 0.87 | 1.53 | 0.324 |
| promyelocytes | 1.09 | 0.58 | 2.06 | 0.781 |
| albumin | 0.80 | 0.43 | 1.48 | 0.478 |
| log(LDH) | 1.03 | 0.66 | 1.60 | 0.910 |
| bilirubin | 1.27 | 0.59 | 2.76 | 0.545 |
| creatinine | 0.60 | 0.15 | 2.45 | 0.476 |
| BM Blast | 1.00 | 1.00 | 1.00 | 0.036 |
| Cytogenetics = Favorable (vs. Others) | 0.24 | 0.08 | 0.67 | 0.007 |
| MR1-2 (Positive vs. Negative) | 3.24 | 1.57 | 6.68 | 0.002 |
| MR3-7 (Positive vs. Negative) | 75.15 | 15.02 | 375.87 | <0.001 |
| MR8+ (Positive vs. Negative) | 14.58 | 5.03 | 42.25 | <0.001 |
| Response=CRp or CRi (vs. CR) | 5.21 | 2.15 | 12.62 | 0.0003 |
| FLT3 ITD positive (vs. Other) | 1.41 | 0.63 | 3.17 | 0.401 |
| FLT3 ITD negative/NPM1 positive (vs. Other) | 0.60 | 0.23 | 1.60 | 0.310 |
| Treatment = CIA (vs. FLAG) | 3.93 | 1.38 | 11.20 | 0.010 |
| Treatment = CLIA (vs. FLAG)* | <0.001 | <0.001 | NA | 0.991 |
| Treatment = FAI (vs. FLAG) | 2.66 | 0.75 | 9.50 | 0.131 |
*
Not estimable due to no events (i.e., relapse or death) in the CLIA group due to short follow-up. The FLAG regimens was used only for patients with CBF leukemia confounding the outcomes.