Table 2b.
Univariate Cox regression analysis for overall survival.
| Covariate | HR | 95% CI | P value | |
|---|---|---|---|---|
| Age | 1.02 | 0.99 | 1.04 | 0.253 |
| log(WBC) | 0.89 | 0.66 | 1.20 | 0.446 |
| HGB | 1.05 | 0.82 | 1.35 | 0.675 |
| log(PLT) | 1.07 | 0.74 | 1.54 | 0.737 |
| log(Blast) | 0.86 | 0.68 | 1.10 | 0.236 |
| log(monocytes) | 0.95 | 0.71 | 1.28 | 0.753 |
| log(neutrophils) | 1.14 | 0.83 | 1.57 | 0.431 |
| promyelocytes | 1.34 | 0.75 | 2.43 | 0.325 |
| albumin | 0.94 | 0.50 | 1.76 | 0.839 |
| log(LDH) | 1.20 | 0.73 | 1.96 | 0.474 |
| bilirubin | 1.10 | 0.48 | 2.54 | 0.818 |
| creatinine | 0.54 | 0.12 | 2.49 | 0.430 |
| BM Blast | 1.00 | 1.00 | 1.00 | 0.058 |
| Cytogenetics = Favorable (vs. Others) | 0.14 | 0.03 | 0.58 | 0.007 |
| MR1-2 (Positive vs. Negative) | 4.28 | 1.85 | 9.90 | 0.001 |
| MR3-7 (Positive vs. Negative) | 15.11 | 5.43 | 42.05 | <0.001 |
| MR8+ (Positive vs. Negative) | 10.97 | 3.27 | 36.81 | <0.001 |
| Response=CRp or CRi (vs. CR) | 3.14 | 1.09 | 9.04 | 0.034 |
| FLT3 ITD positive (vs. Other) | 1.98 | 0.82 | 4.78 | 0.130 |
| FLT3 ITD negative/NPM1 positive (vs. Other) | 0.57 | 0.19 | 1.69 | 0.310 |
| Treatment = CIA (vs. FLAG) | 6.62 | 1.57 | 27.85 | 0.010 |
| Treatment = CLIA (vs. FLAG)* | <0.001 | <0.001 | NA | 0.993 |
| Treatment = FAI (vs. FLAG) | 4.45 | 0.81 | 24.50 | 0.09 |
*
Not estimable due to no events (i.e., death) in the CLIA group due to short follow-up. The FLAG regimens was used only for patients with CBF leukemia confounding the outcomes.