Table 3a. Multivariate analysis of covariates for relapse-free survival.
Parameter | Hazard ratio (95% confidence interval) | P value |
---|---|---|
At Response (1 – 2 months from Therapy Initiation) (N=166) | ||
| ||
Age | 1.03 (1.00, 1.07) | 0.08 |
Cyto (Fav vs. others) | 0.24 (0.07, 0.81) | 0.02 |
Response (CRi/CRp vs. CR) | 2.39 (0.92, 6.24) | 0.07 |
MRD at CR | 2.83 (1.31, 6.09) | 0.008 |
| ||
During Consolidation (3 – 7 Months from Therapy Initiation) (N=116) | ||
| ||
Age | 1.00 (0.97, 1.04) | 0.82 |
Cyto (Fav vs. others) | 0.46 (0.15, 1.42) | 0.17 |
Response (CRi/CRp vs. CR) | 1.28 (0.39, 4.19) | 0.68 |
MRD at 3-7 Months | 50.38 (9.18, 276.63) | <0.0001 |
| ||
At Completion of Therapy (≥ 8 Months from Therapy Initiation) (N=69)* | ||
| ||
Age | 1.00 (0.96, 1.05) | 0.91 |
Cyto (Fav vs. others) | 0.98 (0.27, 3.62) | 0.98 |
MRD at ≥ 8 Months | 12.98 (3.82, 44.12) | <0.0001 |
The effect of response cannot be estimated because among the 65 evaluable patients, only 1 patient had CRp, the remaining 64 patients all had CR.