Table 3b. Multivariate Cox regression analysis of covariates for overall survival.
Parameter | Hazard ratio (95% confidence interval) | P value |
---|---|---|
At Response (1 – 2 months from Therapy Initiation) (N=166) | ||
| ||
Age | 1.05 (1.00, 1.09) | 0.05 |
Cyto (Fav vs. Others) | 0.07 (0.01, 0.57) | 0.01 |
Response (CRi/CRp vs. CR) | 1.06 (0.34, 3.30) | 0.93 |
MRD at CR | 5.17 (1.98, 13.49) | 0.0008 |
| ||
During Consolidation (3 – 7 Months from Therapy Initiation) (N=116) | ||
| ||
Age | 1.00 (0.96, 1.04) | 0.89 |
Cyto (Fav vs. Others) | 0.42 (0.09, 1.97) | 0.27 |
Response (CRi/CRp vs. CR) | 0.88 (0.22, 3.46) | 0.85 |
MRD at 3-7 Months | 12.57 (3.94, 40.07) | <0.0001 |
| ||
At Completion of Therapy (≥ 8 Months from Therapy Initiation) (N=69)* | ||
| ||
Age | 1.01 (0.97, 1.06) | 0.60 |
Cyto (Fav vs. Others) | 0.91 (0.14, 5.75) | 0.92 |
MRD at ≥ 8 Months | 10.19 (2.34, 44.34) | 0.002 |
The effect of response cannot be estimated because among the 65 evaluable patients, only 1 patient had CRp, the remaining 64 patients all had CR.