Table 1.
Loci associated with familial intracranial aneurysms by linkage analysis
| Associated Loci | Study Population(s) | OMIM Locus name | OMIM number | Studied in > 1 population | Study Cohort [affected (unaffected)] | References |
|---|---|---|---|---|---|---|
| 1p36.13-p34.3 | North American, Dutch | ANIB3 | 609,122 | Yes | 12(8) from 1 family 7(10) from 1 family |
Nahed et al. (2005) Ruigrok et al. (2008) |
| 2p13 | Dutch | - | - | No | 7(9) from 1 familya | Roos et al. (2004) |
| 4q32.2 | FIA Study | - | - | Yes | 192 familiesb,c
333 familiesb,c |
Foroud et al. (2008) Foroud et al. (2009) |
| 5p15.2-p14.3 | French-Canadian | ANIB4 | 610,213 | No | 9(3) from 1 family | Verlaan et al. (2006) |
| 5q22–33 | Japanese | - | - | No | 104 ASP from 85 families | Onda et al. (2001) |
| 7q11.2 | Japanese, North American | ANIB1 | 105,800 | Yes | 104 ASP from 85 families 39(0) from 13 families |
Onda et al. (2001) Farnham et al. (2004) |
| 8p22 | South Korean | ANIB11 | 614,252 | No | 9(22) from 5 families | Kim et al. (2011) |
| 11q24-q25 | Colombian, North American | ANIB7 | 612,161 | Yes | 2 familiesb | Osturk et al. (2006) |
| 12p12.3 | FIA Study | - | - | Yes | 333 families | Foroud et al. (2009) |
| 13q14.12-q21.1 | French-Canadian | - | - | No | 10(25) from 1 family | Santiago-Sim et al. (2009) |
| 14q22 | Japanese | - | - | No | 104 ASP from 85 families | Onda et al. (2001) |
| 14q23 | Colombian, North American | ANIB8 | 612,162 | Yes | 2 familiesb | Ozturk et al. (2006) |
| 17cen | Japanese | - | - | No | 93(27) from 29 families | Yamada et al. (2004) |
| 19q13 | Finnish, Japanese | ANIB2 | 608,542 | Yes | 48 ASP from 22 families 222 ARP from 121 families 93(27) from 29 families 41(0) from 9 families |
Olson et al. (2002) van der Voet et al. (2004) Yamada et al. (2004) Mineharu et al. (2007) |
| Xp22 | North American, Japanese, Dutch | ANIB5 | 330,870 | Yes | 48 ASP from 22 families 93(27) from 29 families 7(10) from 1 family |
Olson et al. (2002) Yamada et al. (2004) Ruigrok et al. (2008) |
Study cohort data corresponds with the reference in each horizontal row. ASP Affected sib-pair; ARP Affected relative pair
aFamily is consanguineous
bThe number of affected and unaffected individuals included in the linkage analysis was not available
cA total of 1155 affected and 1895 unaffected family members were genotyped in Foroud et al. (2008) and Foroud et al. (2009). Families were enrolled at recruitment sites located in North America, New Zealand, and Australia