Table 2.

Loci associated with intracranial berry aneurysms through genome-wide association studies

Associated Loci	Study Population(s)	OMIM Locus name	OMIM number	Replicated in > 1 population	Size(s) of Study Cohort	References
2q33.1	Dutch, Finnish, Japanese	ANIB9	612,586	Yes	2196 cases; 8085 controls	Bilguvar et al. (2008)
4q31.22	Japanese	-	-	No	2431 cases; 12,696 controls	Low et al. (2012)
4q31.23	Dutch, Finnish, Japanese	-	-	Yes	5891 cases; 14,181 controls	Yasuno et al. (2010) Yasuno et al. (2011)
5q31.3	Finnish, Dutch	-	-	Yes	2335 cases; 9565 controls	Kurki et al. (2014)
8q11.12–12.1	Dutch, Finnish Japanese	ANIB10	612,587	Yes	2196 cases; 8085 controls 5891 cases; 14,181 controls 406 cases; 392 controls 1483 cases; 1683 controls	Bilguvar et al. (2008) Yasuno et al. (2010) Deka et al. (2010) Foroud et al. (2012)
8q21.3	Dutch, Finnish, Japanese	-	-	Yes	5891 cases; 14,181 controls	Yasuno et al. (2010)
9p21.3	Dutch, Finnish, Japanese, Portuguese	ANIB6	611,892	Yes	2196 cases; 8085 controls 5891 cases; 14,181 controls 406 cases; 392 controls 1483 cases; 1683 controls 4133 cases; 7869 controls 2431 cases; 12,696 controls 200 cases; 499 controls	Bilguvar et al. (2008) Yasuno et al. (2010) Deka et al. (2010) Foroud et al. (2012) Foroud et al. (2014) Low et al. (2012) Abrantes et al. (2015)
10q24.32	Dutch, Finnish, Japanese	-	-	Yes	5891 cases; 14,181 controls	Yasuno et al. (2010)
12q22	Dutch, Finnish Japanese	-	-	Yes	5891 cases; 14,181 controls	Yasuno et al. (2011)
13q13.1	Dutch, Finnish Japanese	-	-	Yes	5891 cases; 14,181 controls	Yasuno et al. (2010)
18q11.2	Dutch, Finnish, Japanese	-	-	Yes	5891 cases; 14,181 controls	Yasuno et al. (2010)
20p12.1	Dutch, Finnish, Japanese	-	-	Yes	5891 cases; 14,181 controls	Yasuno et al. (2011)

The size of each study cohort corresponds with the reference in the same horizontal row. Yasuno et al. (2010) and Yasuno et al. (2011) analyzed the same discovery and replication cohorts, which were expanded on from the cohort studied in Bilguvar et al. (2008)