Figure 1.

ΔeGFR in PROTCL and BFC subgroups and combined group. Box plots show median and IQR, with whiskers representing data within 1.5 the IQR of the upper and lower quartiles, with outliers >1.5 and <3.0 IQR as + and >3.0 IQR as *. Horizontal lines to right of box plots indicate the mean value. Nine patients with BFC who either had missing follow-up data (n = 2), or eGFR <20 ml/min per 1.73 m² at time of biopsy (n = 7) have been excluded (Supplementary Table S1c). The “combined” group includes all patients with PROTCL and BFC, and have been split into “deteriorating” and “stable” subgroups, based on the relationship to the median ΔeGFR in each of the PROTCL and BFC subgroups. *Deteriorating group contains patients with ΔeGFR below or equal to the median in each of PROTCL and BFC groups (n = 27). The median ΔeGFR in this subgroup is −14.4 ml/min per 1.73 m² (IQR 15.5). Stable group contains patients with ΔeGFR above the median from each of the PROTCL and BFC groups (n = 25). The median ΔeGFR for this group is 0.3 ml/min per 1.73 m² (IQR 6.0).

**Mann-Whitney U test.