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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Trends Pharmacol Sci. 2016 Dec 2;38(2):181–194. doi: 10.1016/j.tips.2016.11.002

Figure 4.

Figure 4

Effects of Continuous Treatment with the Monoamine Uptake Inhibitor (+)-Methylphenidate on Choice between (+)-Methamphetamine and Food in Rhesus Monkeys (N = 4) [15]. (A,B) Saline and methylphenidate treatment effects on methamphetamine choice dose–effect functions. Top and middle abscissae: unit methamphetamine dose in milligrams per kilogram per injection (log scale). Top Left ordinate: percent methamphetamine choice. Top Right ordinate: percent food choice. Middle ordinate: rates of responding in responses per second. (C) Summary data for response requirement completions ‘choices’ for the total session (total choices), food choices, and methamphetamine choices summed across all methamphetamine doses. All points and bars represent mean ± S.E.M. obtained during days 5–7 of each treatment period. Filled symbols and asterisks indicate statistically different (P <0.05) from continuous saline treatment conditions (+ saline) within a methamphetamine dose. Numbers in parentheses denote the number of subjects contributing to that data point if less than the total number of subjects tested. This indicates that a subject failed to complete at least one response requirement during that component of the choice session.