Figure 1.

R_h trends with N in proteins. Solid and open circles are IDPs^21-39 and folded proteins,^16,40,41 respectively. The trend for folded proteins, R_h = 4.65·N^0.30, was determined from the inset plot and is shown by the dashed line. The trend for chemically denatured proteins, R_h = 2.21·N^0.57, from Wilkins¹⁶ is shown by the solid line. R_h is reported in Å. Inset: Plot of log R_h and log N for the folded proteins, which gave a linear slope and y-intercept of 0.298 (v ~ 0.30) and 0.667 (R_o = antilog (0.667) ~ 4.65), respectively.